Daktarin Oral Gel 40g
A broad spectrum antifungal gel specifically formulated to treat oral thrush.
Miconazole possesses an antifungal activity against the common dermatophytes and yeasts as well as an antibacterial activity against certain gram-positive bacilli and cocci. Its activity is based on the inhibition of the ergosterol biosynthesis in fungi and the change in the composition of the lipid components in the membrane, resulting in fungal cell necrosis.
Restricted to 1 pack only
This is a Pharmacist only procuct.You will be contacted by a pharmacist.
Classification
Pharmacist Only Medicine
Active Ingredients
A white, homogenous, orange-flavoured oral gel containing miconazole 20 mg/g. The other ingredients are glycerol, purified water, pregelatinised potato starch, ethanol, polysorbate 20, sodium saccharin, orange flavour, and cocoa flavour.
Dosage
Infants: For infants 6-24 months, one quarter (1/4) of a measuring spoon* of gel four times daily, or 20 mg/kg/day is recommended.
Children (2years of age and older) and Adults: Half (1/2) a measuring spoon* of gel four times daily.
*A measuring spoon (5 mL) is provided with the gel. One spoonful contains approximately 124 mg of miconazole. All spoonful dose volumes should be administered with this spoon.
DAKTARIN oral gel should be placed on the tongue and kept in mouth for as long as possible before swallowing. When treating infants and younger children it is recommended that the measured dose of gel be given in several portions in the front of the mouth. Avoid dosing to the back of the throat to prevent obstruction. With oral thrush in elderly patients where a contributing cause is the dental prosthesis it is recommended that DAKTARIN oral gel be applied directly to the dentures in the evening and left on overnight. The treatment should be continued for at least one week after the symptoms have disappeared and generally until all clinical and mycological laboratory tests no longer indicate that active fungal infection is present.
Warnings
DAKTARIN Oral Gel is contraindicated in the following situations:
* In patients with a known hypersensitivity to miconazole or to any of the other ingredients of the gel.
* In infants less than 6 months of age or in those whose swallowing reflex is not yet sufficiently developed.
* In patients with liver dysfunction.
* Co-administrating of the following drugs that are subject to metabolism by CYP3A4 (see Interactions):
o Substrates known to prolong the QT-interval eg. Astemizole, bepridil, cisapride, dofetilide, halofantrine, mizolastine, pimozide, quinidine, sertindole and terfenadine.
o Ergot alkaloids.
o HMG-CoA reductase inhibitors such as simvastatin and lovastatin.
o Triazolam and oral midazolam.
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